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    Research Consortia
    KRICT-Rega Institute KU Leuven
    Research Project
    • Development of Therapeutic and Vaccine Candidates via the Advancement of a Pandemic Response Platform
    Consortium Members
    Type Domestic Institution International Institution
    Lead Korea Research Institute of Chemical Technology REGA Institute for Medical Research (KU Leuven)
    Partner Seoul National University
    Korea Research Institute of Bioscience and Biotechnology
    Commissioned Sungkyunkwan University
    Research Summary
    Purpose
    • Establish an international joint research platform for next-generation vaccine development targeting Disease X, and discover promising vaccine candidates.
    Research Content
    • Utilize chemical compound libraries and ultra-high-throughput automated efficacy evaluation platforms to screen therapeutic candidates.
    • Build and operate in vitro and in vivo evaluation platforms for vaccine and therapeutic candidates.
    • Discover preclinical candidates and construct a platform for large-scale vaccine production processes.
    Consortium Features
    Domestic Institutions
    • Equipped with cutting-edge research infrastructure and facilities capable of conducting complex chemical and biological analyses.
    • Proven track record in nonclinical evaluations and technology transfer for human vaccines.
    • Host institution of the International Vaccine Institute (IVI), possessing integrated evaluation protocols covering efficacy assessment, nonclinical, and clinical research for vaccine candidates.
    International Institutions
    • Possess state-of-the-art laboratory equipment, such as high-risk, fully automated, high-throughput “Pathogen-IN, Human-OUT Lab in a Box” systems for preclinical drug discovery.
    • Maintain an extensive international network that includes academic groups and pharmaceutical companies engaged in antiviral drug development.
    Outcomes, Applications & Expected Impact
    Utilization of Research Outcomes
    • Construct the world’s largest virus-compound efficacy evaluation map (MAP).
    • Enable proactive, national-level responses to Disease X through data sharing with researchers and key institutions domestically and internationally.
    Rapid Pandemic Response via Joint Research
    • Leverage the established efficacy evaluation database to accelerate decision-making during public health emergencies and deliver optimal treatment strategies.
    • Facilitate the development of therapeutic and vaccine products by expediting the transition from preclinical candidates to applied solutions.
    Researchers (PI)
    • Soo bong Han Director of Infectious Diseases Therapeutic Research Center
      Korea Research Institute of Chemical Technology (KRICT)
      Main research areas
      • Discovery and development of antiviral drugs
      • Protein structure-based small molecule drug design
      • Drug optimization through synthetic medicinal chemistry
      • Research on enhancing safety and pharmacological activity
      • Research on bioactive small molecules
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    • Daesub Song Professor
      Seoul National University (College of Veterinary Medicine)
      Main research areas
      • Pathogenesis of virus infection
      • Interspecies transmission of zoonotic disease
      • Development of viral vaccine and therapeutics
      • Preclinical evaluation
      • Detection and Diagnostic for viral disease
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    • Dae Gwin Jeong Principal Researcher
      Korea Research Institute of Bioscience and Biotechnology
      Main research areas
      • Development of recombinant protein vaccines based on protein structure
      • Immunodiagnosis using virus antigen-antibody
      • Commercialization of animal infection virus vaccines
      • One Health virus surveillance research
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    • In Su Kim Professor
      Sungkyunkwan University
      Main research areas
      • C-H Functionalization
      • Synthesis and Transformation of Complex Heterocyclic Molecules
      • Late-Stage Drug Optimization
      • Development of Anticancer/Antidiabetic/Antiviral Candidates
      • Total Synthesis of Bioactive Natural Products
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    • Johan Neyts Laboratory of Virology & Antiviral Research
      Rega Institute for Medical Research
      Main research areas
      • Discovery and development of antiviral drugs
      • Research on Viral Replication Mechanisms and Pathogenesis
      • Research on Antiviral Drug Resistance and Viral Evolution
      • Vaccine Development Based on Virus Vector Technology
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